PARD3
PARD3 Gene Summary
This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | PARD3 |
| Official Name | par-3 family cell polarity regulator [Source:HGNC Symbol;Acc:HGNC:16051] |
| Ensembl ID | ENSG00000148498 |
| Bio databases IDs | |
| Aliases | par-3 family cell polarity regulator, atypical PKC isotype-specific interacting protein, par-3 family cell polarity regulator alpha, protein phosphatase 1, regulatory subunit 118 |
| Synonyms | ASIP,atypical pkc-specific binding,Baz,circPard3,D8Ertd580e,MPAR3,PAR3,PAR3A,PAR3alpha,par-3 family cell polarity regulator,PARD3A,Phip,PPP1R118,SE2-5,SE2-5L16,SE2-5LT1,SE2-5T2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- activation domain
- protein phosphatase binding
- CR1 domain
- canonical PDZ domain
- aPKC binding domain
- coiled-coil domain
- protein binding
- PDZ domain
- identical protein binding
- N-terminal of Par3 and HAL proteins
- phosphatidylinositol binding
- phosphatidylinositol-3,4,5-triphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- cpPDZ_Deg_HtrA-like
- PDZ binding motif
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the PARD3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ATP2A2
- CDH1
- HSPA5
- ESR1
- ANXA1
- ESR2
- IQGAP1
- MYC
- SIRT2
- CDC42
disease
- neoplasia
- epithelial neoplasia
- benign neoplasia
- cancer
- papillomatosis
- neural tube defect
- metastasis
- edema
- growth failure
- prostate cancer
regulated by
- beta-estradiol
- TGFB1
- camptothecin
- MIAT
- PI3K (complex)
- cyclosporin A
- HIF1A
- lithium chloride
- PLCB3
- phytohemagglutinin
regulates
- STAT3
- JNK
- ERK1/2
- AKT
- GSK3B
- NFkB (complex)
- IL6
- D-glucose
- actin
- F Actin
role in cell
- phosphorylation in
- expression in
- activation in
- apoptosis
- proliferation
- migration
- number
- synthesis in
- production in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- low-density microsomal fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell junction
- axon component
- spindle apparatus
- Cytoplasm
- cell periphery
- cellular membrane
- Nucleus
- microtubules
- microtubule tips
- intercellular junctions
- cell-cell contacts
- cytosol
- primary cilia
- acrosome
- growth cone
- paranodal loops
- neurites
- paranodes
- nerve ending
- myelin sheath
- synaptosomes
- Schmidt-Lanterman incisures
- anchoring junction
- tight junctions
- junctional complexes
- apical cell-cell contacts
- perikaryon
- axons
- axonal shafts
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PARD3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- macromolecular complex assembly
- establishment or maintenance of cell polarity
- protein localization
- asymmetric cell division
- cell adhesion
- establishment of epithelial cell polarity
- microtubule cytoskeleton organization
- protein kinase C-activating G-protein coupled receptor signaling pathway
- protein targeting to membrane
- myelination in peripheral nervous system
- establishment of centrosome localization
- negative regulation of peptidyl-threonine phosphorylation
- establishment or maintenance of epithelial cell apical/basal polarity
- axonogenesis
- tight junction assembly
- establishment of cell polarity
- positive regulation of myelination
CELLULAR COMPONENT
Where in the cell the gene product is active
- plasma membrane
- adherens junction
- tight junction
- occluding junction
- cytoskeleton
- cell-cell junction
- cell cortex
- apical junction complex
- internode region of axon
- cytosol
- endomembrane system
- cell junction
- apical plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- phosphatidylinositol binding
- phosphatidylinositol-3-phosphate binding