CDH22

CDH22 Gene Summary

This gene is a member of the cadherin superfamily. The gene product is composed of five cadherin repeat domains and a cytoplasmic tail similar to the highly conserved cytoplasmic region of classical cadherins. Expressed predominantly in the brain, this putative calcium-dependent cell adhesion protein may play an important role in morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine organs. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
CDH22
Official Name
cadherin 22 [Source:HGNC Symbol;Acc:HGNC:13251]
Ensembl ID
ENSG00000149654
Bio databases IDs NCBI: 64405 Ensembl: ENSG00000149654
Aliases cadherin 22
Synonyms
C20orf25,cadherin 22,dJ998H6.1,Pb-Cadherin
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Cadherin, Y-type LIR-motif
  • cytoplasmic domain
  • Cadherin repeat-like domain

Pathways

Biological processes and signaling networks where the CDH22 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • UBC
  • AKAP5
  • CTNNB1
disease
  • COVID-19
  • age-related macular degeneration
  • diabetic nephropathy
  • metabolic syndrome X
  • infection by HIV-1
regulated by
  • IL1B
  • IFNG
  • thyroid hormone
  • TP73
  • FFAR3
  • IKZF1
  • NR4A3
  • NFkB (complex)
  • INPP5D
regulates
role in cell

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the CDH22 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • calcium-dependent cell-cell adhesion
  • cell-cell junction assembly
  • adherens junction organization
  • multicellular organismal development
  • cell morphogenesis
  • cell-cell adhesion mediated by cadherin
  • homophilic cell adhesion
  • cell migration

CELLULAR COMPONENT

Where in the cell the gene product is active
  • adherens junction
  • catenin complex

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • cadherin binding
  • calcium ion binding
  • beta-catenin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.