CCR9

CCR9 Gene Summary

The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta chemokine receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance. This gene maps to the chemokine receptor gene cluster. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]

Details

Type
Protein Coding
Official Symbol
CCR9
Official Name
C-C motif chemokine receptor 9 [Source:HGNC Symbol;Acc:HGNC:1610]
Ensembl ID
ENSG00000173585
Bio databases IDs NCBI: 10803 Ensembl: ENSG00000173585
Aliases C-C motif chemokine receptor 9
Synonyms
A130091K22RIK,CC-CKR-9,C-C motif chemokine receptor 9,CDw199,Cmkbr10,GPR28,GPR-9-6
Species
Human, homo_sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor
  • C-C chemokine receptor
  • Cholecystokinin A receptor, N-terminal
  • chemokine receptor
  • 7 transmembrane receptor (rhodopsin family)
  • protein binding
  • seven-transmembrane G protein-coupled receptor superfamily

Pathways

Biological processes and signaling networks where the CCR9 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • TRPM4
  • YWHAE
  • SPNS1
  • OSTC
  • SAP130
  • vercirnon
  • TMC6
  • CCL25
  • NPHP4
  • RXRA
disease
  • rheumatoid arthritis
  • Crohn disease
  • COVID-19
  • T acute lymphoblastic leukemia
  • atherosclerosis
  • colorectal cancer
  • critical COVID-19
  • insulin-dependent diabetes mellitus
regulated by
  • tretinoin
  • lipopolysaccharide
  • sirolimus
  • TP53
  • E. coli B5 lipopolysaccharide
  • IL5
  • cyclosporin A
  • semaxinib
  • IL4
  • captopril
regulates
  • ERK1/2
  • Ca2+
  • NADPH oxidase
  • AKT
  • DHX32
  • TPPP3
  • TFDP1
  • PI3K (complex)
  • CBFB
  • CASP3
role in cell
  • expression in
  • chemotaxis
  • migration
  • response
  • differentiation
  • number
  • abnormal morphology
  • quantity
  • development
  • cellular subpopulation ratio

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cell surface
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the CCR9 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • chemotaxis
  • cellular defense response
  • immune response
  • CD8-positive, gamma-delta intraepithelial T cell differentiation
  • G-protein coupled receptor signaling pathway
  • chemokine-mediated signaling pathway
  • calcium-mediated signaling
  • elevation of cytosolic calcium ion concentration
  • cell chemotaxis

CELLULAR COMPONENT

Where in the cell the gene product is active
  • external side of plasma membrane
  • plasma membrane
  • cell surface

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • C-C chemokine binding
  • C-C chemokine receptor activity
  • chemokine receptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.