TPPP3 Gene Summary [Human]
Enables tubulin binding activity. Involved in decidualization and microtubule bundle formation. Colocalizes with microtubule bundle and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TPPP3 |
| Official Name | tubulin polymerization promoting protein family member 3 [Source:HGNC Symbol;Acc:HGNC:24162] |
| Ensembl ID | ENSG00000159713 |
| Bio databases IDs | |
| Aliases | tubulin polymerization promoting protein family member 3 |
| Synonyms | 2700055K07Rik, Ceacam9, CGI-38, mmCGM8, p20, p25gamma, RGD1305061, TPPP/p20, tubulin polymerization-promoting protein family member 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TPPP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tubulin binding
- p25-alpha
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- glioblastoma cancer
- rotator cuff injury
- glioblastoma
- Ullrich congenital muscular dystrophy
- recurrent implantation failure
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- proliferation
- expression in
- invasion by
- apoptosis
- migration
- downregulation in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- microtubule bundles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TPPP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule bundle formation
- positive regulation of protein polymerization
- microtubule polymerization
- decidualization
- embryo implantation
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- tubulin binding