KCNJ9 Gene Summary
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KCNJ9 |
| Official Name | potassium inwardly rectifying channel subfamily J member 9 [Source:HGNC Symbol;Acc:HGNC:6270] |
| Ensembl ID | ENSG00000162728 |
| Bio databases IDs | |
| Aliases | potassium inwardly rectifying channel subfamily J member 9, G protein-activated inward rectifier potassium channel 3 |
| Synonyms | 1700085N21RIK,GIRK3,KIR3.3,mbGIRK3,potassium inwardly rectifying channel subfamily J member 9,potassium inwardly-rectifying channel, subfamily J, member 9 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein activated inward rectifier potassium channel
- Inward rectifier potassium channel C-terminal domain
- Inward rectifier potassium channel transmembrane domain
- protein binding
- ion channel
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the KCNJ9 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
- presynaptic membrane
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the KCNJ9 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- regulation of ion transmembrane transport
cellular COMPONENT
Where in the cell the gene product is active
- presynaptic membrane
- ion channel complex
- plasma membrane
molecular FUNCTION
What the gene product does at the molecular level
- G-protein activated inward rectifier potassium channel activity
- protein binding
- inward rectifier potassium channel activity