Kcnj9 Gene Summary [Mouse]

Contributes to G-protein activated inward rectifier potassium channel activity. Involved in regulation of presynaptic membrane potential. Part of inward rectifier potassium channel complex. Is active in parallel fiber to Purkinje cell synapse and presynaptic membrane. Is expressed in central nervous system; eye; intestine; and male reproductive gland or organ. Orthologous to human KCNJ9 (potassium inwardly rectifying channel subfamily J member 9). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Kcnj9
Official Name
potassium inwardly-rectifying channel, subfamily J, member 9 [Source:MGI Symbol;Acc:MGI:108007]
Ensembl ID
ENSMUSG00000038026
Bio databases IDs NCBI: 16524 Ensembl: ENSMUSG00000038026
Aliases potassium inwardly-rectifying channel, subfamily J, member 9
Synonyms 1700085N21RIK, GIRK3, KIR3.3, mbGIRK3, potassium inwardly rectifying channel subfamily J member 9, potassium inwardly-rectifying channel, subfamily J, member 9
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnj9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein activated inward rectifier potassium channel
  • Inward rectifier potassium channel C-terminal domain
  • Inward rectifier potassium channel transmembrane domain
  • protein binding
  • ion channel
  • PDZ-domain binding

Pathways

Biological processes and signaling networks where the Kcnj9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • seizures
  • major depression
regulated by
regulates
role in cell
  • excitation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • Endoplasmic Reticulum
  • presynaptic membrane
  • excitatory synapses

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnj9 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of ion transmembrane transport

Cellular Component

Where in the cell the gene product is active
  • presynaptic membrane
  • ion channel complex
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • G-protein activated inward rectifier potassium channel activity
  • protein binding
  • inward rectifier potassium channel activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.