PAPOLA Gene Summary [Human]
The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Processed Transcript |
| Official Symbol | PAPOLA |
| Official Name | poly(A) polymerase alpha [Source:HGNC Symbol;Acc:HGNC:14981] |
| Ensembl ID | ENSG00000090060 |
| Bio databases IDs | |
| Aliases | poly(A) polymerase alpha |
| Synonyms | PAP, PAP-alpha, PapIII, PAP-α, Plap, POLYA POLYMERASE, POLY(A) POLYMERASE alpha, POLY(A) POLYMERASE α |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PAPOLA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Poly(A) polymerase central domain
- Poly(A) polymerase predicted RNA binding domain
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- nucleotidyltransferase
- ATP binding
- cyclin recognition motif
- enzyme
- protein binding
- manganese ion binding
- magnesium ion binding
Pathways
Biological processes and signaling networks where the PAPOLA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Hutchinson-Gilford progeria syndrome
- oligoarticular juvenile idiopathic arthritis
role in cell
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
- synapse
- perikaryon
- postsynaptic density
- excitatory synapses
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PAPOLA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- RNA binding
- manganese ion binding