Nab1 Gene Summary [Mouse]
Predicted to enable transcription coregulator activity. Acts upstream of or within several processes, including endochondral ossification; nervous system development; and regulation of epidermis development. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; lung epithelium; and paraxial mesenchyme. Orthologous to human NAB1 (NGFI-A binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nab1 |
| Official Name | Ngfi-A binding protein 1 [Source:MGI Symbol;Acc:MGI:107564] |
| Ensembl ID | ENSMUSG00000002881 |
| Bio databases IDs | |
| Aliases | Ngfi-A binding protein 1 |
| Synonyms | EGR1 binding protein 1, NGFI-A binding protein 1, TRANSCRIPTIONAL REGULATORY protein p54 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nab1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ncd1 domain
- transcription regulator
- NAB conserved region 1 (NCD1)
- NAB conserved region 2 (NCD2)
- transcription factor binding
- Conserved region in Nab1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- rheumatoid arthritis
- systemic lupus erythematosus
- psoriasis
- tremor
- epidermal hyperplasia
- primary biliary cirrhosis
- hyperkeratosis
- polymyositis
- systemic sclerosis
role in cell
- proliferation
- expression in
- differentiation
- survival
- development
- abnormal morphology
- endochondral ossification by
- myelination
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nab1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Schwann cell differentiation
- negative regulation of transcription, DNA-dependent
- regulation of epidermis development
- endochondral ossification
- regulation of transcription, DNA-dependent
- myelination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- transcription factor binding