Dusp4 Gene Summary [Mouse]
Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in several processes, including dephosphorylation; endoderm formation; and negative regulation of ERK1 and ERK2 cascade. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in nervous system; olfactory epithelium; and unsegmented mesenchyme. Orthologous to human DUSP4 (dual specificity phosphatase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dusp4 |
| Official Name | dual specificity phosphatase 4 [Source:MGI Symbol;Acc:MGI:2442191] |
| Ensembl ID | ENSMUSG00000031530 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 4 |
| Synonyms | 2700078F24Rik, dual specificity phosphatase 4, E130306H24Rik, HVH2, MKP-2, TYP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dusp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein tyrosine/serine/threonine phosphatase
- protein-tyrosine-phoshatase
- phosphoprotein phosphatase
- protein serine/threonine phosphatase
- protein tyrosine/threonine phosphatase
- Rhodanese Homology Domain
- protein binding
- Rhodanese-like domain
- PTP_DSP_cys
- RHOD
- Dual specificity phosphatase, catalytic domain
- arginine rich motif
- MAP kinase phosphatase
- phosphatase
Pathways
Biological processes and signaling networks where the Dusp4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastrointestinal neoplasia
- Waldenström macroglobulinemia
- hyperplasia
- Sézary syndrome
- Rett syndrome
- juvenile-onset systemic lupus erythematosus
- breast cancer
- organismal death
- esophageal squamous cell carcinoma
role in cell
- cell death
- expression in
- apoptosis
- proliferation
- accumulation in
- molecular cleavage in
- quantity
- growth
- migration
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dusp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAPK cascade
- negative regulation of ERK1 and ERK2 cascade
- endoderm formation
- dephosphorylation
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine/threonine phosphatase activity
- protein tyrosine phosphatase activity
- MAP kinase tyrosine phosphatase activity
- phosphatase activity
- MAP kinase tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity