Atg3 Gene Summary [Mouse]
Enables Atg12 transferase activity and Atg8-family ligase activity. Involved in autophagosome assembly; mitochondrial fragmentation involved in apoptotic process; and regulation of cilium assembly. Acts upstream of or within macroautophagy and negative regulation of phagocytosis. Predicted to be part of Atg12-Atg5-Atg16 complex and cytoplasmic ubiquitin ligase complex. Predicted to be active in cytosol and phagophore assembly site. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human ATG3 (autophagy related 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg3 |
| Official Name | autophagy related 3 [Source:MGI Symbol;Acc:MGI:1915091] |
| Ensembl ID | ENSMUSG00000022663 |
| Bio databases IDs | |
| Aliases | autophagy related 3 |
| Synonyms | 2610016C12Rik, APG3, APG3L, APG3-LIKE, Atg3l, autophagy related 3, hApg3, PC3-96, PIG-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin-like protein transferase activity
- catalytic domain
- APG12 conjugating enzyme
- enzyme binding
- Autophagocytosis associated protein, active-site domain
- APG8 conjugating enzyme
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Atg3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart disease
- prostate cancer
- acute myocardial infarction
- survival
- mitochondrial disorder
role in cell
- degradation in
- expression in
- apoptosis
- cell death
- phosphorylation in
- cell viability
- formation
- expansion
- survival
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atg3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- protein transport
- mitochondrial fragmentation involved in apoptotic process
- protein targeting to membrane
- mitochondrion degradation
- protein ubiquitination
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- pre-autophagosomal structure
- Atg12-Atg5-Atg16 complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- Atg12 ligase activity
- small conjugating protein ligase activity
- Atg8 ligase activity
- enzyme binding