Ednra Gene Summary [Mouse]
Enables endothelin receptor activity. Involved in several processes, including cellular response to gonadotropin stimulus; circulatory system development; and neuron differentiation. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; neural crest cell development; and regulation of D-glucose transmembrane transport. Is active in plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and genitourinary system. Used to study mandibulofacial dysostosis with alopecia and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ednra |
| Official Name | endothelin receptor type A [Source:MGI Symbol;Acc:MGI:105923] |
| Ensembl ID | ENSMUSG00000031616 |
| Bio databases IDs | |
| Aliases | endothelin receptor type A |
| Synonyms | AEA001, Endor, endothelin receptor type A, Et1 receptor, ET-A, ET-AR, ETA receptor, ETRA, Gpcr10, hET-AR, LOC100366209, MFDA, Mhdaaea1, RGD1559432 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ednra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- transmembrane domain
- endothelin receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Ednra gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- corrected congenital pulmonary arterial hypertension
- WHO functional class II-IV idiopathic pulmonary arterial hypertension
- atrial septal defect
- primary pulmonary hypertension
- idiopathic scoliosis
- pulmonary hypertension
- metastasis
- chronic thromboembolic pulmonary hypertension
- heritable pulmonary artery hypertension
phenotypes
- abnormal craniofacial morphology
- abnormal facial morphology
- preweaning lethality complete penetrance
- aberrant origin of the right subclavian artery
- abnormal Meckel's cartilage morphology
- abnormal alisphenoid bone morphology
- abnormal alveolar process morphology
- abnormal artery morphology
- abnormal ascending aorta morphology
- abnormal basisphenoid bone morphology
- abnormal cardiovascular system morphology
- abnormal carotid artery morphology
- abnormal craniofacial bone morphology
- abnormal cranium morphology
- abnormal dorsal aorta morphology
- abnormal ear shape
- abnormal facial nerve morphology
- abnormal first pharyngeal arch morphology
- abnormal fourth pharyngeal arch artery morphology
- abnormal gonial bone morphology
- abnormal heart development
- abnormal heart morphology
- abnormal heart ventricle morphology
- abnormal hyoid bone morphology
- abnormal incudomalleolar joint morphology
- abnormal inspiratory capacity
- abnormal jaw morphology
- abnormal malleus morphology
- abnormal mandible morphology
- abnormal mandibular condyloid process morphology
- abnormal mandibular nerve branching
- abnormal mandibular nerve morphology
- abnormal mandibular ramus morphology
- abnormal masseter muscle morphology
- abnormal maxilla morphology
- abnormal middle ear ossicle morphology
- abnormal mouth floor morphology
- abnormal mouth morphology
- abnormal muscle morphology
- abnormal orbit morphology
- abnormal outer ear helix morphology
- abnormal outer ear morphology
- abnormal palate morphology
- abnormal palatine bone morphology
- abnormal pharyngeal arch artery morphology
- abnormal pterygoid process morphology
- abnormal pulmonary ventilation
- abnormal respiration
- abnormal sixth pharyngeal arch artery morphology
- abnormal skeleton morphology
- abnormal sphenoid bone morphology
- abnormal stapes morphology
- abnormal styloid process morphology
- abnormal temporal bone morphology
- abnormal temporal bone petrous part morphology
- abnormal temporal bone squamous part morphology
- abnormal temporal bone zygomatic process morphology
- abnormal temporomandibular joint morphology
- abnormal third pharyngeal arch artery morphology
- abnormal trigeminal nerve morphology
- abnormal vital capacity
- abnormal zygomatic arch morphology
- abnormal zygomatic bone morphology
- absent Meckel's cartilage
- absent gonial bone
- absent incus
- absent incus short process
- absent malleus
- absent right subclavian artery
- absent salivary gland
- absent stapes
- absent submandibular gland
- absent temporal bone squamous part
- absent temporal bone zygomatic process
- absent tubotympanic recess
- absent tympanic membrane
- absent tympanic ring
- absent vibrissae
- anteriorly rotated ears
- aorta tubular hypoplasia
- cleft chin
- conductive hearing loss
- decreased body size
- decreased body weight
- decreased lung compliance
- decreased prepulse inhibition
- decreased startle reflex
- decreased total lung capacity
- double aortic arch
- double outlet right ventricle
- ectopic thymus
- eyelids open at birth
- impaired hearing
- increased or absent threshold for auditory brainstem response
- incudomalleolar fusion
- interrupted aorta
- lower jaw to upper jaw transformation
- lowered ear position
- macrophthalmia
- malocclusion
- mandible hypoplasia
- micrognathia
- no abnormal phenotype detected
- overriding aortic valve
- patent ductus arteriosus
- perimembraneous ventricular septal defect
- perinatal lethality complete penetrance
- persistent right 6th pharyngeal arch artery
- persistent right dorsal aorta
- persistent truncus arteriosis
- prominent cheeks
- round face
- round orbits
- short mandible
- short mandibular coronoid process
- short snout
- short styloid process
- shortened head
- small mandibular condyloid process
- small second pharyngeal arch
- small zygomatic bone
- thymus hypoplasia
- tongue hypoplasia
- transposition of great arteries
- upper jaw to lower jaw transformation
- wide coronal suture
- wide lambdoid suture
- wide sagittal suture
role in cell
- expression in
- production in
- apoptosis
- accumulation
- growth
- proliferation
- migration
- chemotaxis
- formation
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- nuclear envelope
- transverse tubules
- membrane rafts
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ednra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- norepinephrine metabolic process
- glomerular filtration
- cardiac neural crest cell migration involved in outflow tract morphogenesis
- face development
- cellular response to follicle-stimulating hormone stimulus
- sympathetic nervous system development
- cellular response to luteinizing hormone stimulus
- enteric nervous system development
- response to hypoxia
- cardiac chamber formation
- in utero embryonic development
- protein kinase A signaling cascade
- protein transmembrane transport
- neural crest cell fate commitment
- G-protein coupled receptor signaling pathway
- respiratory gaseous exchange
- left ventricular cardiac muscle tissue morphogenesis
- glomerular endothelium development
- regulation of glucose transport
- aorta development
- renal albumin absorption
- positive regulation of cation channel activity
- gene expression
- artery smooth muscle contraction
- neuron remodeling
- cell proliferation
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- axonogenesis involved in innervation
- sodium ion homeostasis
- response to wounding
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- middle ear morphogenesis
- vasoconstriction
- mitotic cell cycle
- mesenchymal cell apoptotic process
- developmental pigmentation
- atrial cardiac muscle tissue development
- patterning of blood vessels
- smooth muscle contraction
- calcium ion transmembrane transport
- canonical Wnt receptor signaling pathway
- heparin metabolic process
- activation of adenylate cyclase activity
- signal transduction
- neuromuscular process
- phospholipase C-activating G-protein coupled receptor signaling pathway
- embryonic heart tube development
- embryonic skeletal system development
- regulation of blood pressure
- establishment of endothelial barrier
- vascular smooth muscle cell development
- mitochondrion organization
- elevation of cytosolic calcium ion concentration
- cellular calcium ion homeostasis
- renal sodium ion absorption
- noradrenergic neuron differentiation
- regulation of heart rate
- blood vessel remodeling
- thyroid gland development
- response to amphetamine
- axon extension
- glomerular visceral epithelial cell differentiation
- cellular response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- endothelin receptor activity