Psmb8 Gene Summary [Mouse]
Predicted to enable endopeptidase activity. Involved in fat cell differentiation. Acts upstream of or within antigen processing and presentation. Part of proteasome core complex and spermatoproteasome complex. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 1. Orthologous to human PSMB8 (proteasome 20S subunit beta 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmb8 |
| Official Name | proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) [Source:MGI Symbol;Acc:MGI:1346527] |
| Ensembl ID | ENSMUSG00000024338 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) |
| Synonyms | 20s proteosome subunit, ALDD, Beta 5i, beta 5I IMMUNOPROTEASOME subunit, D6S216, D6S216E, JMP, large multifunctional protease-7, LMP7, Lmp8, LOC103690099, NKJO, PRAAS1, proteasome 20S subunit beta 8, proteasome 20S subunit β 8, proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7), proteasome (prosome, macropain) subunit, β type 8 (large multifunctional peptidase 7), proteasome subunit Y, PSMB5i, Rc1, RING10, β 5i, β 5I IMMUNOPROTEASOME subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmb8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- proteasomal presequence
- peptidase
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the Psmb8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- plasma cell myeloma
- secretory multiple myeloma
- symptomatic multiple myeloma
- dextran sodium sulfate-induced colitis
- autoinflammation, lipodystrophy, and dermatosis syndrome
- IgA nephropathy
- atrial fibrillation
- relapsed multiple myeloma
- primary Sjögren syndrome
role in cell
- expression in
- apoptosis
- degradation in
- formation in
- survival
- activation
- cellular infiltration by
- differentiation
- number
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- neurites
- clastosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmb8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- antigen processing and presentation
- fat cell differentiation
- regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- proteasome core complex
- cytosol
- proteasome complex
- proteasome core complex, beta-subunit complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity
- threonine-type endopeptidase activity