Myh1 Gene Summary [Mouse]
Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction. Located in A band and intercalated disc. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; integumental system; and skeletal musculature. Orthologous to human MYH1 (myosin heavy chain 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myh1 |
| Official Name | myosin, heavy polypeptide 1, skeletal muscle, adult [Source:MGI Symbol;Acc:MGI:1339711] |
| Ensembl ID | ENSMUSG00000056328 |
| Bio databases IDs | |
| Aliases | myosin, heavy polypeptide 1, skeletal muscle, adult |
| Synonyms | A530084A17Rik, HEL71, IId, IId/x, MdMs, Mhc2d, MHC-2X/D, Mhc i, MHC-IIx, Mhc iix(d), MHC type1 SLOW, MYHa, MYHC, MyHC-2x, MyHC-2X/D, Myhc i, Myhc iid, MyHC-IId/x, MYHC-IIX, MyHC-IIx/d, MYHSA1, Myhs-f, Myhs-f2, myosin heavy chain 1, myosin heavy chain-I, Myosin heavy chain type iix, myosin, heavy polypeptide 1, skeletal muscle, adult |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Synaptonemal complex protein 1 (SCP-1)
- microfilament motor protein
- Myosin N-terminal SH3-like domain
- helix-rich Mycoplasma protein
- enzyme
- Golgin subfamily A member 5
- ATPase
- Laminin Domain I
- chromosome segregation protein SMC, common bacterial type
- Tropomyosin
- HOOK protein coiled-coil region
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Weak chloroplast movement under blue light
- Myosin and Kinesin motor domain
- Domain of unknown function (DUF4618)
- rad50
- Myosin tail
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Myosin head (motor domain)
- Alpha helical coiled-coil rod protein (HCR)
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- Coiled-coil domain-containing protein 158
- Intermediate filament protein
- Septation ring formation regulator, EzrA
- Myosin
Pathways
Biological processes and signaling networks where the Myh1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- perinuclear region
- intercellular junctions
- sarcomere
- myofibrils
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle contraction
Cellular Component
Where in the cell the gene product is active
- muscle myosin complex
- cytoplasm
- myosin II complex
- myosin filament
- intercalated disc
- A band
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- calmodulin binding
- protein binding
- microfilament motor activity