Myh4 Gene Summary [Mouse]
Predicted to enable actin filament binding activity; double-stranded RNA binding activity; and microfilament motor activity. Acts upstream of or within response to muscle activity. Predicted to be located in myofibril. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in several structures, including brown fat; heart; limb segment; paraxial mesenchyme; and skeletal musculature. Orthologous to human MYH4 (myosin heavy chain 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myh4 |
| Official Name | myosin, heavy polypeptide 4, skeletal muscle [Source:MGI Symbol;Acc:MGI:1339713] |
| Ensembl ID | ENSMUSG00000057003 |
| Bio databases IDs | |
| Aliases | myosin, heavy polypeptide 4, skeletal muscle |
| Synonyms | MHC2B, Minimsc, Minmus, MM, MYH-2B, MyHC-2B, MyHC-IIb, Myhsf, MYO2B, myosin heavy chain 4, Myosin heavy chain type iib, myosin, heavy polypeptide 4, skeletal muscle, β MyHC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myh4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Synaptonemal complex protein 1 (SCP-1)
- Myosin N-terminal SH3-like domain
- helix-rich Mycoplasma protein
- enzyme
- Laminin Domain I
- chromosome segregation protein SMC, common bacterial type
- double-stranded RNA binding
- rod domain
- HOOK protein coiled-coil region
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Weak chloroplast movement under blue light
- Myosin and Kinesin motor domain
- rad50
- Myosin tail
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Myosin head (motor domain)
- Alpha helical coiled-coil rod protein (HCR)
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- Intermediate filament protein
- Apolipoprotein A1/A4/E domain
- Septation ring formation regulator, EzrA
- Myosin
Pathways
Biological processes and signaling networks where the Myh4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agranulocyte Adhesion and Diapedesis
- Calcium Signaling
- Cellular Effects of Sildenafil (Viagra)
- Epithelial Adherens Junction Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- ILK Signaling
- Phagosome Formation
- Protein Kinase A Signaling
- RhoGDI Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- papillomatosis
- developmental disorder
- papilloma
- cryptorchidism
- muscle weakness
regulates
role in cell
- morphology
- number
- abnormal morphology
- extension
- size
- reorganization
- atrophy
- trafficking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell borders
- perinuclear region
- cell cortex
- Nucleus
- Plasma Membrane
- cell-cell contacts
- cytoplasmic face of plasma membrane
- dendritic spines
- paranodes
- myofibrils
- anchoring junction
- gap junctions
- junctional complexes
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myh4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle contraction
- ATP metabolic process
- actin filament-based movement
- muscle filament sliding
Cellular Component
Where in the cell the gene product is active
- muscle myosin complex
- cytoplasm
- myosin II complex
- myosin filament
- sarcomere
- myofibril
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- actin filament binding
- ATP binding
- calmodulin binding
- double-stranded RNA binding
- microfilament motor activity