MYOCD
MYOCD Gene Summary
This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | MYOCD |
| Official Name | myocardin [Source:HGNC Symbol;Acc:HGNC:16067] |
| Ensembl ID | ENSG00000141052 |
| Bio databases IDs | |
| Aliases | myocardin |
| Synonyms | BSAC2A,MGBL,MYCD,Myocardin,Srfcp |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- transcription regulator
- transcription co-activator
- RPEL repeat
- SAP motif
- SAP domain
- transcription activation domain
- transcription factor binding
- histone deacetylase binding
- leucine zipper domain
- protein binding
- glutamine-rich domain
- histone acetyltransferase binding
Pathways
Biological processes and signaling networks where the MYOCD gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- H3
- TAGLN
- HSP90 (family)
- ZNF467
- NCOA3
- SRF
- FBXO32
- MYH11
- H4c14
- FOXF2
disease
- metastasis
- soft tissue sarcoma cancer
- epithelial cancer
- prostate cancer
- Alzheimer disease
- atherosclerosis
- vascular dissection
- growth failure
- fibrosis
- prostatic carcinoma
regulated by
- Ca2+
- APOE
- TNF
- KLF4
- ANO1
- propylthiouracil
- cyclosporin A
- AGT
- TGFB1
- TP53
regulates
- XBP1
- mir-145
- TAGLN
- EIF2AK3
- FN1
- SRF
- BCL2L1
- mir-133 (includes others)
- CASP3
- MYL11
role in cell
- expression in
- binding in
- activation in
- proliferation
- production in
- quantity
- loss
- apoptosis
- migration
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MYOCD gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- uterus development
- ventricular cardiac muscle cell differentiation
- positive regulation of cell proliferation
- ductus arteriosus closure
- regulation of smooth muscle cell differentiation
- cardiac ventricle development
- vasculogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of smooth muscle contraction
- regulation of phenotypic switching
- negative regulation of transcription from RNA polymerase II promoter
- lung alveolus development
- smooth muscle cell differentiation
- response to hypoxia
- cardiac muscle cell apoptotic process
- cardiac vascular smooth muscle cell differentiation
- digestive tract development
- positive regulation of transcription, DNA-dependent
- negative regulation of myotube differentiation
- cardiac muscle cell differentiation
- negative regulation of cell adhesion molecule production
- urinary bladder development
- positive regulation of gene expression, epigenetic
- cardiac cell differentiation
- negative regulation of beta-amyloid clearance
- regulation of cell growth by extracellular stimulus
- cardiac muscle cell myoblast differentiation
- negative regulation of cyclin-dependent protein kinase activity
- cellular component maintenance
- positive regulation of cardiac muscle cell differentiation
- regulation of myoblast differentiation
- positive regulation of smooth muscle cell differentiation
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway
- negative regulation of cardiac muscle cell apoptotic process
- negative regulation of skeletal muscle cell differentiation
- positive regulation of transforming growth factor beta receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- chromatin
MOLECULAR FUNCTION
What the gene product does at the molecular level
- histone acetyltransferase binding
- protein binding
- transcription coactivator activity
- histone deacetylase binding
- R-SMAD binding