TACR1 Gene Summary [Human]
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]
Details
| Type | Protein Coding |
| Official Symbol | TACR1 |
| Official Name | tachykinin receptor 1 [Source:HGNC Symbol;Acc:HGNC:11526] |
| Ensembl ID | ENSG00000115353 |
| Bio databases IDs | |
| Aliases | tachykinin receptor 1, substance-P receptor, neurokinin receptor 1 |
| Synonyms | NEUROKININ-1 receptor, neurokinin substype 1 receptor, NK1R, NK1 receptor, NKIR, SPR, TAC1R, tachykinin receptor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TACR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- tachykinin receptor
- Cholecystokinin A receptor, N-terminal
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- substance P receptor
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- glycosylation site
Pathways
Biological processes and signaling networks where the TACR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- cancer
- Huntington disease
- pain
- neoplasia
- major depression
- chemotherapy sickness
- organismal death
- vomiting
- nausea
role in cell
- expression in
- proliferation
- degradation in
- apoptosis
- production in
- phosphorylation in
- activation in
- cell death
- degranulation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cell periphery
- cellular membrane
- endosomes
- cytoplasmic face of plasma membrane
- postsynaptic membrane
- endosomal compartment
- sperm midpiece
- sperm tail
- sperm head
- synaptosomes
- extracellular matrix
- membrane rafts
- membrane processes
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TACR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm ejaculation
- positive regulation of synaptic transmission, GABAergic
- response to progesterone stimulus
- angiotensin-mediated drinking behavior
- positive regulation of vasoconstriction
- associative learning
- tachykinin receptor signaling pathway
- eating behavior
- response to ethanol
- regulation of smooth muscle cell proliferation
- inflammatory response
- aggressive behavior
- positive regulation of lymphocyte proliferation
- behavioral response to pain
- response to auditory stimulus
- positive regulation of synaptic transmission, cholinergic
- positive regulation of epithelial cell migration
- response to electrical stimulus
- regulation of smooth muscle cell migration
- positive regulation of epithelial cell proliferation
- detection of abiotic stimulus
- response to ozone
- positive regulation of hormone secretion
- response to nicotine
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of blood pressure
- elevation of cytosolic calcium ion concentration
- positive regulation of ossification
- positive regulation of vascular permeability
- long-term memory
- positive regulation of leukocyte migration
- positive regulation of uterine smooth muscle contraction
- positive regulation of action potential
- positive regulation of stress fiber assembly
- response to estradiol stimulus
- smooth muscle contraction involved in micturition
- operant conditioning
Cellular Component
Where in the cell the gene product is active
- dendrite
- sperm midpiece
- cell body
- sperm flagellum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- substance P receptor activity
- tachykinin receptor activity