ADIPOR2 Gene Summary [Human]
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
Details
| Type | Processed Transcript |
| Official Symbol | ADIPOR2 |
| Official Name | adiponectin receptor 2 [Source:HGNC Symbol;Acc:HGNC:24041] |
| Ensembl ID | ENSG00000006831 |
| Bio databases IDs | |
| Aliases | adiponectin receptor 2 |
| Synonyms | 1110001I14RIK, ACDCR2, ADCR2, Adiponectin receptor 2, AI115388, D6Ucla1e, PAQR2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADIPOR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Haemolysin-III related
- hormone binding
- signaling receptor activity
- channel protein, hemolysin III family
- protein-hormone receptor
- protein binding
- identical protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the ADIPOR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- diabetes mellitus
- insulin resistance
- Alzheimer disease
- hyperglycemia
- nonalcoholic steatohepatitis
- impaired glucose tolerance
role in cell
- growth
- apoptosis
- expression in
- cell death
- binding
- M2 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- zona pellucida
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADIPOR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid oxidation
- vascular wound healing
- glucose homeostasis
- adiponectin-mediated signaling pathway
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- adipokinetic hormone receptor activity
- identical protein binding
- protein binding
- metal ion binding
- adiponectin binding
- signaling receptor activity