FABP4 Gene Summary [Human]
FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FABP4 |
| Official Name | fatty acid binding protein 4 [Source:HGNC Symbol;Acc:HGNC:3559] |
| Ensembl ID | ENSG00000170323 |
| Bio databases IDs | |
| Aliases | fatty acid binding protein 4, adipocyte fatty acid binding protein |
| Synonyms | 422/aP2, Adipocyte fatty acid binding, A-fab, A-FABP, ALBP, ALBP/Ap2, AP2, Ap2 lipid-binding, fatty acid binding protein 4, fatty acid binding protein 4, adipocyte, HEL-S-104, Lbpl, P15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FABP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- long-chain fatty acid transporter
- lipocalin/cytosolic fatty acid-binding protein family
- fatty acid binding
- protein binding
- helix-turn-helix domain
- receptor binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the FABP4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphomagenesis
- lung adenocarcinoma formation
- non-small cell lung cancer
- epithelial cancer
- lung cancer
- non-insulin-dependent diabetes mellitus
- prostate cancer
- atopic dermatitis
- endometriosis
- insulin resistance
role in cell
- cell death
- expression in
- formation
- formation in
- production in
- hydrolysis in
- binding
- activation in
- proliferation
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- microvesicles
- Nucleus
- Mitochondria
- lipid droplets
- cytosol
- nucleoplasm
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FABP4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- white fat cell differentiation
- brown fat cell differentiation
- cellular response to lithium ion
- response to bacterium
- long-chain fatty acid transport
- negative regulation of transcription, DNA-dependent
- fatty acid transport
- positive regulation of inflammatory response
- cellular response to tumor necrosis factor
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- lipid particle
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- fatty acid binding
- long-chain fatty acid binding
- hormone receptor binding
- long-chain fatty acid transporter activity