ZNF207 Gene Summary [Human]
Enables microtubule binding activity. Involved in several processes, including mitotic nuclear division; mitotic spindle assembly checkpoint signaling; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matrix. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNF207 |
| Official Name | zinc finger protein 207 [Source:HGNC Symbol;Acc:HGNC:12998] |
| Ensembl ID | ENSG00000010244 |
| Bio databases IDs | |
| Aliases | zinc finger protein 207 |
| Synonyms | 8430401D15Rik, BuGZ, hBuGZ, LOC100043601, LOC100044751, Zep, Zfp207, Zinc finger protein 207 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF207 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- transcription regulator
- intrinsically disordered domain
- protein binding
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- overall survival
- non-small cell lung cancer
- sarcoidosis
role in cell
- expression in
- survival
- alternative splicing in
- proliferation
- activation in
- formation in
- assembly
- binding in
- differentiation
- attachment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
- nucleoli
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF207 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- cell division
- regulation of chromosome segregation
- microtubule bundle formation
- attachment of spindle microtubules to kinetochore
- mitotic sister chromatid segregation
- microtubule polymerization
- protein stabilization
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- spindle
- kinetochore
- nucleolus
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- metal ion binding
- heparin binding
- microtubule binding