SEMA3G Gene Summary [Human]
The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | SEMA3G |
| Official Name | semaphorin 3G [Source:HGNC Symbol;Acc:HGNC:30400] |
| Ensembl ID | ENSG00000010319 |
| Bio databases IDs | |
| Aliases | semaphorin 3G |
| Synonyms | CSG53, RGD1306079, sem2, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G, semaphorin 3G |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEMA3G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- Plexin repeat
- immunoglobulin domain
- protein binding
- receptor binding
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the SEMA3G gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- colon epithelial cancer
- colorectal carcinomagenesis
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- breast carcinoma
- hepatocellular carcinoma
- prostate cancer
regulates
- agar
role in cell
- activation
- colony formation by
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEMA3G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- neural crest cell migration
- negative regulation of axon extension
- axon guidance
- positive regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemorepellent activity
- receptor binding
- semaphorin receptor binding