Sema3g Gene Summary [Mouse]
Enables signaling receptor binding activity. Involved in negative regulation of axon extension. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Is expressed in arterial system; brain; metanephros; and skin. Orthologous to human SEMA3G (semaphorin 3G). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sema3g |
| Official Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G [Source:MGI Symbol;Acc:MGI:3041242] |
| Ensembl ID | ENSMUSG00000021904 |
| Bio databases IDs | |
| Aliases | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G |
| Synonyms | CSG53, RGD1306079, sem2, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G, semaphorin 3G |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema3g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- Plexin repeat
- immunoglobulin domain
- protein binding
- receptor binding
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema3g gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- colon epithelial cancer
- colorectal carcinomagenesis
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- breast carcinoma
- hepatocellular carcinoma
- prostate cancer
regulates
- agar
role in cell
- activation
- colony formation by
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema3g gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- neural crest cell migration
- negative regulation of axon extension
- axon guidance
- positive regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemorepellent activity
- receptor binding
- semaphorin receptor binding