DESI2 Gene Summary [Human]
Enables Lys48-specific deubiquitinase activity; Lys63-specific deubiquitinase activity; and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DESI2 |
| Official Name | desumoylating isopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:24264] |
| Ensembl ID | ENSG00000121644 |
| Bio databases IDs | |
| Aliases | desumoylating isopeptidase 2 |
| Synonyms | 5830417C01Rik, C1orf121, CGI-146, DESI, DESI1, desumoylating isopeptidase 2, FAM152A, PNAS-4, PPPDE1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DESI2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin-specific protease
- PPPDE putative peptidase domain
- enzyme
- protein binding
- acyl-CoA hydrolase
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- colon carcinoma
- colon epithelial cancer
- lung cancer
role in cell
- expression in
- proliferation
- S phase
- apoptosis
- activation in
- breakage in
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DESI2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- proteolysis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- palmitoyl-(protein) hydrolase activity
- long-chain acyl-CoA hydrolase activity