NRP2 Gene Summary [Human]
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Jul 2021]
Details
| Type | Processed Transcript |
| Official Symbol | NRP2 |
| Official Name | neuropilin 2 [Source:HGNC Symbol;Acc:HGNC:8005] |
| Ensembl ID | ENSG00000118257 |
| Bio databases IDs | |
| Aliases | neuropilin 2 |
| Synonyms | 1110048P06RIK, Neuropilin-2, NP2, NPN2, PRO2714, VEGF165R2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NRP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- C-terminal domain of neuropilin glycoprotein
- signaling receptor activity
- Coagulation factor 5/8 C-terminal domain, discoidin domain
- extracellular B domain
- ectodomain
- extracellular A domain
- protein binding
- identical protein binding
- kinase
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- CUB
- transmembrane domain
- coagulation factor domain
- F5/8 type C domain
- vascular endothelial growth factor receptor
- semaphorin receptor
- transmembrane receptor
- MAM domain, meprin/A5/mu
- growth factor binding
- FA58C
Pathways
Biological processes and signaling networks where the NRP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epilepsy
- seizures
- neoplasia
- bleeding
- COVID-19
- diabetic nephropathy
- autism
- hereditary disorder
- non-insulin-dependent diabetes mellitus
- mental retardation
role in cell
- cell death
- expression in
- production in
- proliferation
- activation in
- damage in
- phosphorylation in
- migration
- quantity
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptosomal membrane fractions
- glutaminergic synapse
- cell surface
- cellular membrane
- postsynaptic membrane
- growth cone
- synaptosomes
- synapse
- cytoplasmic vesicles
- membrane processes
- filopodial tip
- perikaryon
- axons
- dendrites
- axon terminals
- apical processes
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NRP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus
- negative chemotaxis
- trigeminal nerve structural organization
- vestibulocochlear nerve structural organization
- vascular endothelial growth factor signaling pathway
- axon guidance
- cell adhesion
- facial nerve structural organization
- nerve development
- axon extension involved in axon guidance
- branchiomotor neuron axon guidance
- outflow tract septum morphogenesis
- angiogenesis
- positive regulation of endothelial cell proliferation
- positive regulation of endothelial cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- semaphorin receptor complex
- postsynaptic membrane
- membrane
- extracellular region
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor binding
- protein binding
- metal ion binding
- signaling receptor activity
- semaphorin receptor activity
- vascular endothelial growth factor-activated receptor activity
- heparin binding
- cytokine binding