LARS2 Gene Summary [Human]
This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LARS2 |
| Official Name | leucyl-tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:17095] |
| Ensembl ID | ENSG00000011376 |
| Bio databases IDs | |
| Aliases | leucyl-tRNA synthetase 2, mitochondrial, leucine tRNA ligase 2, mitochondrial |
| Synonyms | HLASA, Kiaa0028, Leucine--tRNA ligase, leucyl-tRNA synthetase 2, mitochondrial, leucyl-tRNA synthetase, mitochondrial, LEURS, MITOCHONDRIAL TRNA-LEU, mtLeuRS, PRLTS4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LARS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucyl-tRNA synthetase, Domain 2
- isoleucyl-tRNA synthetase
- leucyl-tRNA synthetase, eubacterial and mitochondrial family
- enzyme
- leucine-tRNA ligase
- nucleotidyl transferase superfamily
- valyl-tRNA synthetase
- Anticodon-binding domain of tRNA ligase
- class Ia aminoacyl tRNA synthetases anticodon binding domain
- tRNA synthetases class I (I, L, M and V)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- hydrops, lactic acidosis, and sideroblastic anemia
- Perrault syndrome type 4
- maturity-onset diabetes of the young
- idiopathic scoliosis
- gonadal dysgenesis with auditory dysfunction, autosomal recessive inheritance
- familial nonsyndromic hearing impairment
- myelodysplastic syndrome
- mitochondrial myopathy
regulates
- tRNA-Leu
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LARS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA aminoacylation for protein translation
- leucyl-tRNA aminoacylation
- mitochondrial translation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- ATP binding
- leucine-tRNA ligase activity
- aminoacyl-tRNA editing activity