XRN2 Gene Summary [Human]
This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | XRN2 |
| Official Name | 5'-3' exoribonuclease 2 [Source:HGNC Symbol;Acc:HGNC:12836] |
| Ensembl ID | ENSG00000088930 |
| Bio databases IDs | |
| Aliases | 5'-3' exoribonuclease 2 |
| Synonyms | 5'-3' Exoribonuclease 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human XRN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 5'-3' exonuclease
- nucleic acid binding
- nuclease
- 5'-3' exoribonuclease
- enzyme
- protein binding
- sequence-specific DNA binding
- identical protein binding
- 3'-5' exoribonuclease
- Xrn1 helical domain
- XRN 5'-3' exonuclease N-terminus
- double-stranded DNA binding
- PIN (PilT N terminus) domain: Superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- bladder cancer
- schizophrenia
- childhood attention-deficit hyperactivity disorder
- Ewing sarcoma
- osteosarcomagenesis
role in cell
- proliferation
- expression in
- production in
- degradation in
- migration
- glycolysis in
- processing in
- transcription termination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- aggresome
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human XRN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA metabolic process
- neuron differentiation
- retina development in camera-type eye
- spermatogenesis
- nuclear-transcribed mRNA catabolic process
- RNA processing
- hippocampus development
- mRNA processing
- rRNA processing
- termination of RNA polymerase II transcription
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- nucleolus
- aggresome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 5'-3' exonuclease activity
- 5'-3' exoribonuclease activity
- identical protein binding
- 3'-5'-exoribonuclease activity
- protein binding
- RNA binding
- metal ion binding
- nuclease activity
- transcription termination site sequence-specific DNA binding