Fbxo42 Gene Summary [Mouse]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in brain; glossopharyngeal ganglion; spinal cord; trigeminal ganglion; and vestibulo-cochlear ganglion. Orthologous to human FBXO42 (F-box protein 42). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo42 |
| Official Name | F-box protein 42 [Source:MGI Symbol;Acc:MGI:1924992] |
| Ensembl ID | ENSMUSG00000028920 |
| Bio databases IDs | |
| Aliases | F-box protein 42 |
| Synonyms | 6720460I06Rik, Bc058667, F-box protein 42, Fbx42, JFK, KIAA1332, mKIAA1332 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxo42 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- F-box domain
- Kelch motif
- F-box domain superfamily
- F-box
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- nonalcoholic fatty liver disease
- obesity
- ductal breast carcinoma
- ductal breast cancer
role in cell
- expression in
- phosphorylation in
- degradation in
- BI-2536 sensitivity
- angiogenesis by
- ubiquitination in
- mitotic defect
- TAK-901 sensitivity
- camptothecin resistance
- beta-oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxo42 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding