CNTLN Gene Summary [Human]
Enables protein domain specific binding activity; protein kinase binding activity; and protein-macromolecule adaptor activity. Involved in centriole-centriole cohesion and protein localization to organelle. Located in cytosol; microtubule organizing center; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | CNTLN |
| Official Name | centlein [Source:HGNC Symbol;Acc:HGNC:23432] |
| Ensembl ID | ENSG00000044459 |
| Bio databases IDs | |
| Aliases | centlein |
| Synonyms | B430108F07Rik, bA340N12.1, C9orf101, C9orf39, centlein, centlein, centrosomal protein, D530005L17Rik, LOC103695261, RGD1308101 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CNTLN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RecF/RecN/SMC N terminal domain
- chromosome segregation protein SMC, common bacterial type
- Apg6 coiled-coil region
- protein kinase binding
- Synaptonemal complex protein 1 (SCP-1)
- protein binding activity, bridging
- protein domain specific binding
- helix-rich Mycoplasma protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- COVID-19
- acute myeloid leukemia
- insomnia
- lung adenocarcinoma
- lung adenocarcinoma formation
- alcohol use disorder
- major depression
- hemolytic anemia
- anorexia nervosa
regulates
- protein-protein complex
- RAB3IP
role in cell
- accumulation in
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- centriole
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CNTLN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centriole-centriole cohesion
- protein localization to organelle
Cellular Component
Where in the cell the gene product is active
- centrosome
- extracellular vesicular exosome
- cytoplasm
- centriole
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein domain specific binding
- protein binding, bridging