ITIH4 Gene Summary [Human]
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | ITIH4 |
| Official Name | inter-alpha-trypsin inhibitor heavy chain 4 [Source:HGNC Symbol;Acc:HGNC:6169] |
| Ensembl ID | ENSG00000055955 |
| Bio databases IDs | |
| Aliases | inter-alpha-trypsin inhibitor heavy chain 4, plasma Kallikrein-sensitive glycoprotein |
| Synonyms | GP120, H4P, IHRP, inter alpha-trypsin inhibitor, heavy chain 4, inter-alpha-trypsin inhibitor heavy chain 4, INTER-alpha-TRYPSIN INHIBITOR HEAVY CHAIN-RELATED, inter α-trypsin inhibitor, heavy chain 4, inter-α-trypsin inhibitor heavy chain 4, INTER-α-TRYPSIN INHIBITOR HEAVY CHAIN-RELATED, ITIH4 isoform 1, ITI-HC4, ITIHL1, PK-120 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ITIH4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inter-alpha-trypsin inhibitor heavy chain C-terminus
- marine proteobacterial sortase target protein
- endopeptidase inhibitor
- Vault protein inter-alpha-trypsin domain
- von Willebrand factor (vWF) type A domain
- vWFA
- VWFA-related Acidobacterial domain
- von Willebrand factor type A domain
- protein binding
Pathways
Biological processes and signaling networks where the ITIH4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- epithelial cancer
- major depression
- liver neoplasia
- COVID-19
- neuroticism
- liver cancer
- coronary artery disease
- Huntington disease
- androgenic alopecia
regulates
- reactive oxygen species
- VDR
role in cell
- proliferation
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- Cytoplasm
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ITIH4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- hyaluronan metabolic process
- acute-phase response
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- blood microparticle
- platelet dense granule lumen
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding
- endopeptidase inhibitor activity