SLC2A3 Gene Summary [Human]
Enables dehydroascorbic acid transmembrane transporter activity; glucose binding activity; and glucose transmembrane transporter activity. Involved in glucose import across plasma membrane and transport across blood-brain barrier. Is integral component of plasma membrane. Biomarker of Alzheimer's disease; acanthosis nigricans; diabetes mellitus; and type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLC2A3 |
| Official Name | solute carrier family 2 member 3 [Source:HGNC Symbol;Acc:HGNC:11007] |
| Ensembl ID | ENSG00000059804 |
| Bio databases IDs | |
| Aliases | solute carrier family 2 member 3 |
| Synonyms | GLUT1, GLUT3, LOC100909595, solute carrier family 2 (facilitated glucose transporter), member 3, solute carrier family 2 member 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC2A3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hexose transporter
- benzoate transport
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- glucose binding
- phosphate:H+ symporter
- galactose transporter
- protein binding
- monosaccharide transporter
- organic anion transporter
- galactoside binding
- monosaccharide binding
- kinase binding
- Sugar (and other) transporter
- extracellular loop
- transporter
Pathways
Biological processes and signaling networks where the SLC2A3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- endometriosis
- glioblastoma cancer
- Alzheimer disease
- organismal death
- epileptic seizure
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- diabetic nephropathy
- papillary thyroid carcinoma
role in cell
- apoptosis
- activation in
- production in
- cell viability
- phosphorylation in
- expression in
- proliferation
- growth
- acidification in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- high-density microsomal fractions
- intracellular membrane fractions
- synaptic vesicle membrane
- aggresome
- glutaminergic synapse
- Cytoplasm
- perinuclear region
- intracellular membranes
- cellular membrane
- endosomes
- vesicles
- secretory granule membrane
- tertiary granule membrane
- specific granule membrane
- apical cell surfaces
- apical membrane
- caveolae
- synaptic membrane
- alpha granules
- acrosome
- synaptic vesicles
- cytoplasmic vesicles
- membrane rafts
- microvilli
- clathrin-coated vesicles
- parallel fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC2A3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- dehydroascorbic acid transport
- glucose import
- L-ascorbic acid metabolic process
- galactose transport
- fructose transport
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular vesicular exosome
- membrane
- perikaryon
- aggresome
- cell projection
- plasma membrane
- tertiary granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- glucose binding
- protein binding
- D-glucose transmembrane transporter activity
- dehydroascorbic acid transporter activity
- galactose transmembrane transporter activity
- fructose transmembrane transporter activity
- glucose transmembrane transporter activity