PDIA5 Gene Summary [Human]
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PDIA5 |
| Official Name | protein disulfide isomerase family A member 5 [Source:HGNC Symbol;Acc:HGNC:24811] |
| Ensembl ID | ENSG00000065485 |
| Bio databases IDs | |
| Aliases | protein disulfide isomerase family A member 5 |
| Synonyms | 2700053F16Rik, LOC100911928, PDIR, protein disulfide isomerase associated 5, protein disulfide isomerase family A member 5, protein disulfide isomerase family A, member 5, protein DISULFIDE ISOMERASE RELATED, Protein disulfide isomerase related 5, Protein disulfide isomerase related protein 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDIA5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide-isomerase
- protein disulfide isomerase, eukaryotic
- thioredoxin-like domain
- protein disulfide oxidoreductase
- oxidoreductase
- Thioredoxin-like
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein disulfide-isomerase domain
- enzyme
- protein binding
- thioredoxin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDIA5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- electron transport chain
- protein folding
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein disulfide isomerase activity
- protein disulfide oxidoreductase activity
- protein binding
- oxidoreductase activity