TLE2 Gene Summary [Human]
Enables transcription corepressor activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription, DNA-templated. Located in focal adhesion and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TLE2 |
| Official Name | TLE family member 2, transcriptional corepressor [Source:HGNC Symbol;Acc:HGNC:11838] |
| Ensembl ID | ENSG00000065717 |
| Bio databases IDs | |
| Aliases | TLE family member 2, transcriptional corepressor, enhancer of split groucho 2 |
| Synonyms | ESG, ESG2, Gm32024, GRG2, mKIAA4188, TLE family member 2, transcriptional corepressor, transducin-like enhancer of split 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TLE2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- WD40 repeats
- transcription co-repressor
- Groucho/TLE N-terminal Q-rich domain
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- focal adhesions
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TLE2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of transcription, DNA-dependent
- signal transduction
- Wnt receptor signaling pathway
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- extracellular space
- nuclear body
- focal adhesion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity