KDM4A Gene Summary [Human]
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
Details
| Type | Protein Coding |
| Official Symbol | KDM4A |
| Official Name | lysine demethylase 4A [Source:HGNC Symbol;Acc:HGNC:22978] |
| Ensembl ID | ENSG00000066135 |
| Bio databases IDs | |
| Aliases | lysine demethylase 4A, jumonji C domain-containing histone demethylase 3A, tudor domain containing 14A |
| Synonyms | D4Ertd222e, JHDM3A, JMJD2, JMJD2A, LOC230674, lysine demethylase 4A, lysine (K)-specific demethylase 4A, mKIAA0677, TDRD14A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KDM4A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- histone binding
- PHD zinc finger
- jmjN domain
- 2-oxoglutarate:oxygen oxidoreductase
- protein binding activity, bridging
- enzyme
- protein binding
- RmlC-like cupin superfamily
- PHD-finger
- PHD-like zinc-binding domain
- zinc ion binding
- PHD finger superfamily
- Tudor domain superfamily
- histone demethylase activity
- PHD-zinc-finger like domain
- Jumonji domain-containing protein 2A Tudor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- castration refractory prostate cancer
- metastasis
- hypertension
- COVID-19
- opioid-related disorder
- colon adenocarcinoma
- colon epithelial cancer
- IDH1 mutation positive acute myeloid leukemia
role in cell
- invasion by
- expression in
- proliferation
- growth
- activation in
- phosphorylation in
- accumulation in
- apoptosis
- binding in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- cytosol
- nucleoplasm
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KDM4A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- negative regulation of autophagy
- positive regulation of gene expression
- regulation of gene expression
- negative regulation of astrocyte differentiation
- positive regulation of neuron differentiation
- apoptotic chromosome condensation
- response to nutrient levels
- cardiac muscle hypertrophy in response to stress
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- centromeric heterochromatin
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- ubiquitin protein ligase binding
- methylated histone residue binding
- histone demethylase activity (H3-K9 specific)
- histone demethylase activity
- histone demethylase activity (H3-K36 specific)