RASGRP2
RASGRP2 Gene Summary
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Details
| Type | Retained Intron |
| Official Symbol | RASGRP2 |
| Official Name | RAS guanyl releasing protein 2 [Source:HGNC Symbol;Acc:HGNC:9879] |
| Ensembl ID | ENSG00000068831 |
| Bio databases IDs | |
| Aliases | RAS guanyl releasing protein 2, calcium- and diacylglycerol-regulated guanine nucleotide exchange factor I |
| Synonyms | Caldaggef1,CALDAG-GEFI,CDC25L,LOC381240,RAS guanyl releasing protein 2,RAS, guanyl releasing protein 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- Ras exchanger motif
- EF-hand, calcium binding motif
- lipid binding
- EF-hand domain pair
- nuclear localization sequence
- calcium ion binding
- EFh
- Cdc25 domain
- RasGEF
- EF-hand domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- guanyl-nucleotide exchange factor
- EF hand
- zinc finger domain
- REM
Pathways
Biological processes and signaling networks where the RASGRP2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- APP
- F Actin
- CEBPB
- RIGI
- SATB1
- ALAD
- NHLRC2
- CEBPA
- DISP3
- FAM118B
disease
- androgenic alopecia
- platelet-type bleeding disorder type 18
- Huntington disease
- gastrointestinal hemorrhage
- menorrhagia
- epistaxis
- bleeding
- leukocyte adhesion deficiency type I
- essential thrombocythemia
regulated by
- camptothecin
- IL5
- beta-estradiol
- HTT
- CD38
- Ca2+
- FOXP1
- SP3
- SP1
- neutrophils
regulates
- RAP1A
- RAS
- ITGB1
- collagen alpha1
- NRAS
- RAP1
- 5-hydroxytryptamine
- ICAM1
- ITGB3
- ITGA2B
role in cell
- growth
- migration
- activation in
- aggregation
- function
- cell spreading
- adhesion
- cytotoxicity
- response by
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the RASGRP2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cellular response to calcium ion
- regulation of cell growth
- signal transduction
- Ras protein signal transduction
- positive regulation of GTPase activity
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytosol
- ruffle membrane
- synapse
- neuron projection
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- calcium ion binding
- guanyl-nucleotide exchange factor activity
- diacylglycerol binding
- lipid binding