AP1M2 Gene Summary [Human]

This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Details

Type
Protein Coding
Official Symbol
AP1M2
Official Name
adaptor related protein complex 1 subunit mu 2 [Source:HGNC Symbol;Acc:HGNC:558]
Ensembl ID
ENSG00000129354
Bio databases IDs NCBI: 10053 Ensembl: ENSG00000129354
Aliases adaptor related protein complex 1 subunit mu 2
Synonyms adaptor protein complex AP-1, mu 2 subunit, adaptor related protein complex 1 subunit mu 2, AP1-mu2, D9Ertd818e, HSMU1B, [m]1B, MU-1B, mu2, RGD1561490
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AP1M2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • AP_MHD_Cterm
  • Adaptor complexes medium subunit family
  • protein binding
  • Longin-like domains
  • transporter

Pathways

Biological processes and signaling networks where the AP1M2 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • growth failure
  • hypoalbuminemia
  • endometriosis
regulates
role in cell
  • abnormal morphology
  • targeting

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytoplasmic vesicle membrane
  • intracellular membrane-bounded organelle
  • perinuclear region
  • endosomes
  • Golgi Apparatus
  • cytosol
  • Golgi membrane
  • trans Golgi network
  • lysosome membrane
  • recycling endosomes
  • clathrin-coated vesicles

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human AP1M2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • protein targeting
  • vesicle-mediated transport
  • vesicle targeting
  • intracellular protein transport

Cellular Component

Where in the cell the gene product is active
  • cytoplasmic vesicle membrane
  • intracellular membrane-bounded organelle
  • AP-1 adaptor complex
  • cytosol
  • Golgi membrane
  • clathrin-coated vesicle
  • lysosomal membrane
  • trans-Golgi network membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • clathrin adaptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.