MOV10L1 Gene Summary [Human]
This gene is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Details
| Type | Protein Coding |
| Official Symbol | MOV10L1 |
| Official Name | Mov10 like RISC complex RNA helicase 1 [Source:HGNC Symbol;Acc:HGNC:7201] |
| Ensembl ID | ENSG00000073146 |
| Bio databases IDs | |
| Aliases | Mov10 like RISC complex RNA helicase 1, cardiac helicase activated by MEF2C protein |
| Synonyms | CHAMP, Csm, DJ402G11.8, Mov10 like RISC complex RNA helicase 1, Mov10 like RNA helicase 1, SPGF73 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MOV10L1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA helicase domain
- ATP binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- magnesium ion binding
- RNA helicase
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- alcoholism
- azoospermia
- hyperplasia
- spermatogenic failure 73
- male infertility
role in cell
- apoptosis
- migration
- cell death
- size
- abnormal morphology
- cell cycle progression
- meiosis
- meiosis I
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MOV10L1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- posttranscriptional gene silencing by RNA
- spermatogenesis
- male meiosis I
- piRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- P granule
- pi-body
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- magnesium ion binding
- ATP binding
- RNA binding
- RNA helicase activity