ATF7IP Gene Summary [Human]
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]
Details
| Type | Processed Transcript |
| Official Symbol | ATF7IP |
| Official Name | activating transcription factor 7 interacting protein [Source:HGNC Symbol;Acc:HGNC:20092] |
| Ensembl ID | ENSG00000171681 |
| Bio databases IDs | |
| Aliases | activating transcription factor 7 interacting protein |
| Synonyms | 2610204M12RIK, 5830415B17Rik, activating transcription factor 7 interacting protein, AM, ATF7IP1, ATF-IP, LOC108169175, MCAF, MCAF1, p621 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATF7IP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ATP-binding domain
- transcription co-repressor
- Fibronectin-III type domain
- transcription cofactor
- protein binding
- ATF-interacting protein binding domain
- N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins
- zDHHC ankyrin repeat binding domain
- ATPase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- schizophrenia
- Alzheimer disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- cholangiocarcinoma cancer
- liver cancer
- bile duct cancer
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATF7IP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of protein stability
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- protein stabilization
- positive regulation of methylation-dependent chromatin silencing
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- nuclear body
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- protein binding
- transcription cofactor activity
- transcription corepressor activity