PIWIL2 Gene Summary [Human]
PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | PIWIL2 |
| Official Name | piwi like RNA-mediated gene silencing 2 [Source:HGNC Symbol;Acc:HGNC:17644] |
| Ensembl ID | ENSG00000197181 |
| Bio databases IDs | |
| Aliases | piwi like RNA-mediated gene silencing 2, Hiwi-like, cancer/testis antigen 80 |
| Synonyms | CT80, HILI, mili, PIWI2, PIWIL1L, piwi-like RNA-mediated gene silencing 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIWIL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Piwi-like
- mRNA binding
- Argonaute linker 1 domain
- endoribonuclease
- PAZ domain
- enzyme
- protein binding
- PAZ
- Piwi domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ovarian cancer
- breast cancer
- azoospermia
- takotsubo cardiomyopathy
role in cell
- expression in
- proliferation
- apoptosis
- survival
- development
- quantity
- function
- prophase
- abnormal morphology
- early pachytene stage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- perinuclear region
- punctate structures
- Nucleus
- cytosol
- chromosome
- sister chromatids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIWIL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- rhythmic process
- positive regulation of cytoplasmic translation
- positive regulation of meiosis I
- oogenesis
- germ-line stem cell maintenance
- spermatogenesis
- gene silencing by RNA
- negative regulation of circadian rhythm
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatoid body
- cytoplasm
- perinucleolar chromocenter
- P granule
- pi-body
Molecular Function
What the gene product does at the molecular level
- protein binding
- piRNA binding
- metal ion binding
- mRNA binding
- endoribonuclease activity