Mov10l1 Gene Summary [Mouse]
Enables RNA helicase activity and piRNA binding activity. Involved in several processes, including male meiosis I; regulatory ncRNA-mediated gene silencing; and spermatogenesis. Located in pi-body. Is expressed in heart and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 73. Orthologous to human MOV10L1 (Mov10 like RNA helicase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Mov10l1 |
| Official Name | Mov10 like RISC complex RNA helicase 1 [Source:MGI Symbol;Acc:MGI:1891384] |
| Ensembl ID | ENSMUSG00000015365 |
| Bio databases IDs | |
| Aliases | Mov10 like RISC complex RNA helicase 1 |
| Synonyms | CHAMP, Csm, DJ402G11.8, Mov10 like RISC complex RNA helicase 1, Mov10 like RNA helicase 1, SPGF73 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mov10l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA helicase domain
- ATP binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- magnesium ion binding
- RNA helicase
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- alcoholism
- azoospermia
- hyperplasia
- spermatogenic failure 73
- male infertility
role in cell
- apoptosis
- migration
- cell death
- size
- abnormal morphology
- cell cycle progression
- meiosis
- meiosis I
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mov10l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- posttranscriptional gene silencing by RNA
- spermatogenesis
- male meiosis I
- piRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- P granule
- pi-body
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- magnesium ion binding
- ATP binding
- RNA binding
- RNA helicase activity