SRI Gene Summary [Human]
This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | SRI |
| Official Name | sorcin [Source:HGNC Symbol;Acc:HGNC:11292] |
| Ensembl ID | ENSG00000075142 |
| Bio databases IDs | |
| Aliases | sorcin |
| Synonyms | 2210417O06RIK,2900070H08RIK,CP-22,SCN,Sor,Sorcin,Sorcn,V19 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRI often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- protease binding
- EF-hand domain pair
- calcium ion binding
- EFh
- transcription factor binding
- protein binding
- receptor binding
- identical protein binding
- calcium channel regulator
- The penta-EF hand (PEF) family
- EF-hand domain
- ion channel binding
- protein heterodimerization
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- colorectal carcinoma
- colorectal carcinomagenesis
- epithelial cancer
- hereditary disorder
- hepatocellular carcinoma
- organismal death
role in cell
- apoptosis
- expression in
- molecular cleavage in
- G1 phase
- activation in
- phosphorylation in
- migration
- proliferation
- aggregation
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- cellular membrane
- Plasma Membrane
- sarcoplasmic reticulum
- vesicles
- Endoplasmic Reticulum
- Mitochondria
- secretory granule membrane
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
- dendritic spine neck
- Z line
- transverse tubules
- axons
- axon terminals
- exosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRI gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- signal transduction
- regulation of cardiac muscle cell contraction
- regulation of heart contraction
- intracellular sequestering of iron ion
- positive regulation of release of sequestered calcium ion into cytosol
- regulation of striated muscle contraction
- negative regulation of ryanodine-sensitive calcium-release channel activity
- muscle organ development
- heart development
- regulation of cell communication by electrical coupling
- calcium ion transport
- regulation of action potential
- negative regulation of heart rate
- regulation of calcium ion transport
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- negative regulation of cardiac muscle contraction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- T-tubule
- Z disc
- extracellular vesicular exosome
- sarcoplasmic reticulum
- cytoplasm
- membrane
- cytosol
- chromaffin granule membrane
- sarcoplasmic reticulum membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- calcium ion binding
- protease binding
- calcium channel regulator activity
- ion channel binding
- receptor binding