MTREX Gene Summary [Human]
Enables ATP binding activity and RNA helicase activity. Involved in RNA catabolic process; cellular response to DNA damage stimulus; and maturation of 5.8S rRNA. Located in nucleoplasm. Part of TRAMP complex and catalytic step 2 spliceosome. Colocalizes with nuclear exosome (RNase complex). Biomarker of amyotrophic lateral sclerosis. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MTREX |
| Official Name | Mtr4 exosome RNA helicase [Source:HGNC Symbol;Acc:HGNC:18734] |
| Ensembl ID | ENSG00000039123 |
| Bio databases IDs | |
| Aliases | Mtr4 exosome RNA helicase, functional spliceosome-associated protein 118 |
| Synonyms | 2610528A15Rik, Dob1, fSAP118, KIAA0052, mKIAA0052, Mtr4, Mtr4 exosome RNA helicase, RGD1305984, SKIV2L2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTREX often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- rRNA-processing arch domain
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- ATP binding
- enzyme
- DSHCT (NUC185) domain
- protein binding
- Helicase conserved C-terminal domain
- RNA helicase
- 6-pyruvoyl-tetrahydropterin synthase related domain (membrane protein)
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTREX gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of 5.8S rRNA
- snRNA catabolic process
- rRNA processing
- response to DNA damage stimulus
- nuclear mRNA splicing, via spliceosome
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nuclear exosome (RNase complex)
- nucleus
- catalytic step 2 spliceosome
- nuclear speck
- nucleolus
- TRAMP complex
- exosome (RNase complex)
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding
- RNA helicase activity