PRMT7 Gene Summary [Human]
This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PRMT7 |
| Official Name | protein arginine methyltransferase 7 [Source:HGNC Symbol;Acc:HGNC:25557] |
| Ensembl ID | ENSG00000132600 |
| Bio databases IDs | |
| Aliases | protein arginine methyltransferase 7 |
| Synonyms | 4933402B05Rik, protein arginine methyltransferase 7, protein arginine N-methyltransferase 7, RGD1304869, SBIDDS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRMT7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- histone methyltransferase
- ribonucleoprotein binding
- enzyme
- protein binding
- protein-arginine N-methyltransferase
- S-adenosylmethionine-dependent methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- prostate cancer
- epithelial cancer
- short stature, brachydactyly, intellectual developmental disability, and seizures
- hereditary disorder
- hepatocellular carcinoma
- liver cancer
- colorectal cancer
- fibrosis
regulated by
- AGT
- 293t cells
- 293 cells
role in cell
- expression in
- proliferation
- migration
- colony formation
- quantity
- formation
- number
- formation in
- G1 phase
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRMT7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- regulation of protein binding
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
- genetic imprinting
- spliceosomal snRNP assembly
- peptidyl-arginine methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein-arginine omega-N symmetric methyltransferase activity
- protein binding
- histone binding
- histone methyltransferase activity (H4-R3 specific)
- ribonucleoprotein complex binding
- histone methyltransferase activity
- protein-arginine omega-N monomethyltransferase activity
- protein-arginine N-methyltransferase activity
- S-adenosylmethionine-dependent methyltransferase activity