KIF22 Gene Summary [Human]
The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | KIF22 |
| Official Name | kinesin family member 22 [Source:HGNC Symbol;Acc:HGNC:6391] |
| Ensembl ID | ENSG00000079616 |
| Bio databases IDs | |
| Aliases | kinesin family member 22 |
| Synonyms | A-328A3.2, AU021460, C81217, KID, Kif22a, kinesin family member 22, KNSL4, LOC102553262, OBP, OBP-1, OBP-2, SEMDJL2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helix-hairpin-helix domain
- DNA binding domain
- Myosin and Kinesin motor domain
- ATP-binding domain
- nuclear localization sequence
- coiled-coil domain
- protein binding
- motor domain
- Helix-hairpin-helix motif
- head domain
- microtubule motor protein
- DNA binding
- Kinesin motor, catalytic domain
- microtubule binding
- competence protein ComEA helix-hairpin-helix repeat region
- Kinesin motor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- organismal death
- spondyloepimetaphyseal dysplasia with joint laxity type 2
- developmental bone disease
- small cell lung cancer
- melanoma
- melanoma cancer
role in cell
- expression in
- glycolysis in
- proliferation
- apoptosis
- abnormal morphology
- cohesion
- cytokinesis failure in
- cohesion in
- chromosomal congression
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- spindle pole bodies
- cytosol
- chromosome
- spindle pole
- spindle fibers
- nuclear speckles
- mitotic spindle
- kinetochores
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sister chromatid cohesion
- DNA repair
- metaphase plate congression
- microtubule-based movement
- mitotic metaphase plate congression
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitotic spindle
- nuclear speck
- cytosol
- kinesin complex
- kinetochore
- chromatin
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- microtubule motor activity
- protein binding
- microtubule binding