PUM3 Gene Summary [Human]
Enables RNA binding activity. Involved in regulation of protein ADP-ribosylation. Located in chromosome; endoplasmic reticulum; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PUM3 |
| Official Name | pumilio RNA binding family member 3 [Source:HGNC Symbol;Acc:HGNC:29676] |
| Ensembl ID | ENSG00000080608 |
| Bio databases IDs | |
| Aliases | pumilio RNA binding family member 3, penguin homolog (Drosophila), minor histocompatibility antigen HA-8 |
| Synonyms | 1110069H02Rik, D19Bwg1357e, HA-8, HLA-HA8, KIAA0020, PEN, PUF6, PUF-A, pumilio RNA-binding family member 3, XTP5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PUM3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pumilio-family RNA binding domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- epithelial neoplasia
- Alzheimer disease
- adenoma formation
- benign neoplasia
- lymphomagenesis
- organismal death
- lung adenocarcinoma formation
- preeclampsia
role in cell
- expression in
- cell cycle progression
- sub-G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Endoplasmic Reticulum
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PUM3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- regulation of protein ADP-ribosylation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- mRNA binding