ULK2 Gene Summary [Human]
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
Details
| Type | Retained Intron |
| Official Symbol | ULK2 |
| Official Name | unc-51 like autophagy activating kinase 2 [Source:HGNC Symbol;Acc:HGNC:13480] |
| Ensembl ID | ENSG00000083290 |
| Bio databases IDs | |
| Aliases | unc-51 like autophagy activating kinase 2 |
| Synonyms | A830085I22RIK, ATG1B, mKIAA0623, Unc51.2, unc-51 like autophagy activating kinase 2, unc-51 like kinase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ULK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- glioblastoma cancer
- neoplasia
- epithelial cancer
- neoplastic cell transformation
- malignant pleural mesothelioma
- pleural cancer
- mesothelioma formation
- glioblastoma
- lung adenocarcinoma
role in cell
- formation
- proliferation
- apoptosis
- production in
- growth
- phosphorylation in
- autophagy by
- generation in
- degradation in
- arborization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ULK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- response to starvation
- collateral sprouting
- protein autophosphorylation
- mitochondrion degradation
- autophagic vacuole assembly
- negative regulation of collateral sprouting
- positive regulation of autophagy
- piecemeal microautophagy of nucleus
- axon extension
- autophagy
- peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- cytoplasm
- pre-autophagosomal structure membrane
- pre-autophagosomal structure
- cytosol
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity