ZFAND6 Gene Summary [Human]
Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in cellular response to tumor necrosis factor; negative regulation of apoptotic process; and regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZFAND6 |
| Official Name | zinc finger AN1-type containing 6 [Source:HGNC Symbol;Acc:HGNC:30164] |
| Ensembl ID | ENSG00000086666 |
| Bio databases IDs | |
| Aliases | zinc finger AN1-type containing 6, protein associated with PRK1 |
| Synonyms | 3110005P07Rik, AWP1, protein ASSOCIATED with PRK1, ZA20D3, ZFAND5B, zgc:101121, zinc finger AN1-type containing 6, zinc finger, AN1-type domain 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFAND6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- A20-like zinc finger
- protein binding
- AN1-like Zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZFAND6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to peroxisome
- negative regulation of apoptotic process
- protein transport
- apoptotic process
- regulation of I-kappaB kinase/NF-kappaB cascade
- cellular response to tumor necrosis factor
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- polyubiquitin binding