ZW10 Gene Summary [Human]
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | ZW10 |
| Official Name | zw10 kinetochore protein [Source:HGNC Symbol;Acc:HGNC:13194] |
| Ensembl ID | ENSG00000086827 |
| Bio databases IDs | |
| Aliases | zw10 kinetochore protein |
| Synonyms | 6330566F14Rik, HZW10, KNTC1AP, MmZw10, zw10 kinetochore protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZW10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Centromere/kinetochore Zw10
- protein binding
- centromeric DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- binding
- misalignment
- organization
- misalignment in
- mitosis
- disruption in
- spindle checkpoint
- disruption
- prometaphase
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Endoplasmic Reticulum
- lipid droplets
- cytosol
- spindle pole
- kinetochore microtubule
- cell membrane leading edge
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZW10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- macromolecular complex assembly
- retrograde vesicle-mediated transport, Golgi to ER
- Golgi organization
- regulation of exit from mitosis
- protein transport
- cell division
- establishment of mitotic spindle orientation
- meiotic cell cycle
- ER to Golgi vesicle-mediated transport
- mitotic sister chromatid segregation
- protein localization to kinetochore
- regulation of attachment of spindle microtubules to kinetochore
- mitotic metaphase plate congression
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- lipid particle
- nucleus
- kinetochore microtubule
- Dsl1p complex
- membrane
- spindle pole
- cytosol
- endoplasmic reticulum
- kinetochore
Molecular Function
What the gene product does at the molecular level
- protein binding
- centromeric DNA binding