TESC Gene Summary [Human]
Enables calcium ion binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of macromolecule metabolic process; and positive regulation of myeloid cell differentiation. Located in several cellular components, including cytosol; lamellipodium; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | TESC |
| Official Name | tescalcin [Source:HGNC Symbol;Acc:HGNC:26065] |
| Ensembl ID | ENSG00000088992 |
| Bio databases IDs | |
| Aliases | tescalcin, calcineurin-like EF hand protein 3 |
| Synonyms | 1010001A17RIK, 2410011K10RIK, CHP3, FLJ20607, RGD1566317, TE-1, TESCALCIN, TSC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TESC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- phosphatase inhibitor
- EF-hand domain pair
- EF hand
- calcium ion binding
- protein homodimerization
- protein binding
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- Huntington disease
- thyroid carcinoma
- epithelial thyroid cancer
- papillary thyroid carcinoma
- papillary thyroid cancer
- androgenic alopecia
role in cell
- apoptosis
- migration
- phosphorylation in
- expression in
- proliferation
- cell viability
- invasion by
- differentiation
- colony formation by
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TESC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- protein transport
- positive regulation of megakaryocyte differentiation
- regulation of cell adhesion mediated by integrin
- positive regulation of granulocyte differentiation
- positive regulation of sodium:hydrogen antiporter activity
- cellular response to retinoic acid
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- cell differentiation
- protein maturation
- protein stabilization
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- ruffle
- cytosol
- ruffle membrane
- plasma membrane
- nucleoplasm
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- protein homodimerization activity
- protein binding
- calcium ion binding
- phosphatase inhibitor activity
- protein kinase inhibitor activity