Tesc Gene Summary [Mouse]
Enables metal ion binding activity; phosphatase inhibitor activity; and protein homodimerization activity. Involved in male gonad development and megakaryocyte differentiation. Located in several cellular components, including lamellipodium; nucleus; and ruffle. Is expressed in several structures, including adrenal gland; brain; genitourinary system; limb bud; and sensory organ. Orthologous to human TESC (tescalcin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tesc |
| Official Name | tescalcin [Source:MGI Symbol;Acc:MGI:1930803] |
| Ensembl ID | ENSMUSG00000029359 |
| Bio databases IDs | |
| Aliases | tescalcin |
| Synonyms | 1010001A17RIK, 2410011K10RIK, CHP3, FLJ20607, RGD1566317, TE-1, TESCALCIN, TSC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tesc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- phosphatase inhibitor
- EF-hand domain pair
- EF hand
- calcium ion binding
- protein homodimerization
- protein binding
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- Huntington disease
- thyroid carcinoma
- epithelial thyroid cancer
- papillary thyroid carcinoma
- papillary thyroid cancer
- androgenic alopecia
role in cell
- apoptosis
- migration
- phosphorylation in
- expression in
- proliferation
- cell viability
- invasion by
- differentiation
- colony formation by
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tesc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- protein transport
- positive regulation of megakaryocyte differentiation
- regulation of cell adhesion mediated by integrin
- positive regulation of granulocyte differentiation
- positive regulation of sodium:hydrogen antiporter activity
- cellular response to retinoic acid
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- cell differentiation
- protein maturation
- protein stabilization
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- ruffle
- cytosol
- ruffle membrane
- plasma membrane
- nucleoplasm
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- protein homodimerization activity
- protein binding
- calcium ion binding
- phosphatase inhibitor activity
- protein kinase inhibitor activity