MAPKAPK5 Gene Summary [Human]
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | MAPKAPK5 |
| Official Name | MAPK activated protein kinase 5 [Source:HGNC Symbol;Acc:HGNC:6889] |
| Ensembl ID | ENSG00000089022 |
| Bio databases IDs | |
| Aliases | MAPK activated protein kinase 5 |
| Synonyms | LOC100047833, MAPK5, MAPK activated protein kinase 5, MAPKAP kinase 5, MAP kinase-activated protein kinase 5, MK-5, NCFD, PRAK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAPKAPK5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- MAPK binding site
- p53 binding
- protein binding
- Protein kinase domain
- kinase
- MAP kinase kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- hinge domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAPKAPK5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neurocardiofaciodigital syndrome
- chronic obstructive pulmonary disease
- advanced cancer
- cancer
- migraines
- papillomatosis
- epithelial neoplasia
- benign neoplasia
- skin neoplasia
role in cell
- synthesis in
- expression in
- migration
- signaling in
- phosphorylation in
- replicative senescence
- reorganization
- translation in
- reorganization in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAPKAPK5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- stress-induced premature senescence
- cellular senescence
- positive regulation of dendritic spine development
- protein autophosphorylation
- Ras protein signal transduction
- regulation of translation
- MAPK cascade
- positive regulation of telomerase activity
- positive regulation of telomere maintenance via telomerase
- peptidyl-serine phosphorylation
- negative regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- macromolecular complex
- septin cytoskeleton
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- p53 binding
- calmodulin binding
- protein binding
- MAP kinase kinase activity
- calmodulin-dependent protein kinase activity
- mitogen-activated protein kinase binding
- protein serine/threonine kinase activity
- calcium-dependent protein serine/threonine kinase activity