KIF16B Gene Summary [Human]
The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | KIF16B |
| Official Name | kinesin family member 16B [Source:HGNC Symbol;Acc:HGNC:15869] |
| Ensembl ID | ENSG00000089177 |
| Bio databases IDs | |
| Aliases | kinesin family member 16B, sorting nexin 23 |
| Synonyms | 8430434E15Rik, AI789011, C20ORF23, C80902, FLJ23045, KIAA1590, Kif16b predicted, kinesin family member 16B, KISC20ORF, mKIAA1590, SNX23 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF16B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inner membrane component of T3SS, cytoplasmic domain
- Arginine and glutamate-rich 1
- Synaptonemal complex protein 1 (SCP-1)
- helix-rich Mycoplasma protein
- enzyme
- forkhead associated (FHA) domain superfamily
- Chromatin assembly factor 1 complex p150 subunit, N-terminal
- phosphatidylinositol-3,4,5-triphosphate binding
- plus-end-directed kinesin ATPase
- polo kinase kinase
- Domain of unknown function (DUF4515)
- Ezrin/radixin/moesin, alpha-helical domain
- Myosin and Kinesin motor domain
- enzyme binding
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- phosphatidylinositol binding
- Kinesin-associated
- Alpha helical coiled-coil rod protein (HCR)
- Kinesin motor, catalytic domain
- Domain of unknown function (DUF4659)
- microtubule binding
- Fez1
- MAP7 (E-MAP-115) family
- binding protein
- Trichohyalin-plectin-homology domain
- FHA domain
- Kinesin motor domain
- The Phox Homology domain, a phosphoinositide binding module
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metabolic syndrome X
- carcinoma in situ
- epithelial cancer in situ
- carcinoid tumor
- stuttering
- asthma
- Hodgkin lymphoma
- Hodgkin disease
role in cell
- aggregation
- invasion by
- response by
- degradation by
- function in
- degradation
- aggregation in
- trafficking in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- spindle apparatus
- endosomes
- early endosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF16B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- receptor catabolic process
- endoderm development
- epidermal growth factor receptor signaling pathway
- early endosome to late endosome transport
- formation of primary germ layer
- fibroblast growth factor receptor signaling pathway
- microtubule-based movement
- regulation of receptor recycling
- Golgi to endosome transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- endosome
- cytoplasm
- spindle
- cytosol
- kinesin complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- ATPase activity
- ATP binding
- phosphatidylinositol-3,5-bisphosphate binding
- plus-end-directed microtubule motor activity
- phosphatidylinositol-3-phosphate binding
- phosphatidylinositol-3,4-bisphosphate binding
- microtubule binding